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EJNMMI Radiopharmacy and Chemistry
Fig. 4 | EJNMMI Radiopharmacy and Chemistry

Fig. 4

From: Preclinical evaluation of an 18F-labeled Nε-acryloyllysine piperazide for covalent targeting of transglutaminase 2

Fig. 4

Metabolization of [18F]7b toward murine liver microsomes. A, C Exemplary radio-HPLC chromatograms (A) and radio-TLC (C) of [18F]7b after incubation with murine liver microsomes (MLMs) for different time periods. Radiometabolites are indicated by red asterisks. B Time course of residual intact [18F]7b toward incubation with MLMs determined by radio-HPLC and radio-TLC including nonlinear regression according to one-phase decay. The calculated half-life values are given in the box (in min). Conditions: 10 mM PBS (pH 7.4), 1 mg/mL MLM, 2 mM NADPH, 108 MBq/mL or 4.1 µM [18F]7b, 0.2% ethanol (v/v), for control conditions NADPH was replaced by PBS

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