Fig. 2

PET imaging for [¹⁸F]7b in normal mice. A PET images at selected time points after intravenous injection of [¹⁸F]7b in normal mice under control conditions (upper panel, 5.16 MBq) and with co-injection of ketoconazole (lower panel, 7.02 MBq and 3 mg ketoconazole). Images are presented as maximum intensity projections and shown at a common scale (SUV 0–8). Indicated time points correspond to the following time frames: 5 min [4 − 6 min], 30 min [25 − 30 min], 1 h [50 − 60 min], and 2 h [110–120 min]. Anatomical positions of liver (li), kidney (ki), bone (bo), and heart (ht) used for SUV quantification are exemplarily shown for the control mouse. B Standard uptake values (SUV, decay-corrected) for control mouse and ketoconazole treated mouse as a function of time (up to 2 h, in dynamic mode) obtained by PET acquisition (same experiments as in A). Data shown are for one mouse each. For a better orientation, dotted lines at SUVs of 3, 6, and 9 (for liver, kidney and heart) and 5, 10, and 15 (for bone) were drawn. C Summary of calculated AUC_0-2 h values for the curves shown in B