Table 1 IC50 values [µM] for the uncoordinated ligands, their gallium3+ and lutetium3+ metallacages and auranofin against four different tumor cell lines
Compounds | IC50 values (µM) | |||
|---|---|---|---|---|
MCF7 | PC-3 | U373 | U343 | |
H2Ldiethyl | 47.4 ± 4.0 | 34.3 ± 7.2 | > 100 | > 100 |
H2Lmorph | 37.2 ± 4.4 | 41.8 ± 7.1 | 38.8 ± 2.0 | 43.2 ± 1.3 |
[Ga{Au(Ldiethyl)}2]NO3 | 4.6 ± 0.7 | 4.5 ± 0.7 | 6.8 ± 1.6 | 4.0 ± 1.1 |
[Ga{Au(Lmorph)}2]NO3 | 9.5 ± 2.3 | 11.1 ± 1.4 | 23.3 ± 6.5 | 22.9 ± 10.8 |
[Lu{Au(Ldiethyl)}3] | 4.5 ± 0.2 | 2.3 ± 1.9 | 0.8 ± 0.6 | 1.2 ± 0.0 |
[Lu{Au(Lmorph)}3] | 11.8 ± 1.7 | 6.7 ± 3.3 | 8.5 ± 3.1 | 5.0 ± 0.2 |
Auranofin | 3.4 ± 1.9 | 5.0 ± 0.8 | 1.8 ± 0.9 | 1.1 ± 0.1 |