Evaluation of the 177mLu-concentration in in-house produced 177Lu-radiopharmaceuticals and commercially available Lutathera®

EJNMMI Radiopharmacy and Chemistry

Table 1 Overview of suppliers of tests Lu177-precursors; * = ITM, = EZAG, * = Monrol

Probe number	Supplier	Lu177m-impurity on certificate of analysis (%)	Production route	Activity of Lu177m [Bq/g] d.c	Activity of Lu177m [ppm] d.c	Activity of Lu177m [%] d.c	Measurement error [%]
0	1	2	3	4	5	6	7
1–97	EndolucinBeta^®*	< 0.01	n.c.a	381 ± 511^a	0.00037 ± 0.00053^a	0.0000037 ± 0.0000053^a	≤ 4.7
98	¹⁷⁷Lu Lutetiumchloride in aqueous solution **	< 0.007	n.c.a	9521	0.00453	0.0000453	≤ 3.9
99	Lutetium chloride (Lu-177) radiopharmaceutical precursor solution nca ***	not detected	n.c.a	39	0.00002	0.0000002	≤ 3.7
100	LuMark^®	0.00786	c.a	706,594	0.82479	0.008248	≤ 3.0
101–138	Lutathera^® (n = 38, n = 25 for column 4)	< 0.015	c.a	29,512 ± 6491^a	0.96 ± 0.17^a	0.0096 ± 0.0017^a	≤ 2.6