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EJNMMI Radiopharmacy and Chemistry
Fig. 5 | EJNMMI Radiopharmacy and Chemistry

Fig. 5

From: Synthesis and evaluation of a novel PET ligand, a GSK’963 analog, aiming at autoradiography and imaging of the receptor interacting protein kinase 1 in the brain

Fig. 5

Evaluation of [11C]GG502 in a healthy rhesus monkey. A Coronal brain PET images in a rhesus monkey averaged from 0–10, 10–60, and 60–120 min after intravenous injection of [11C]GG502 (top), [11C]GG502 with pre-blocking (bottom). B Time activity curves of whole brain, striatum, cerebellum, medial temporal lobe, and white matter after intravenous injection of [11C]GG502 (red), [11C]GG502 with pre-blocking (blue). Non-radioactive GG502 1 mg/kg intravenous injection was performed 5 min before [11C]GG502 injection in a blocking study

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