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EJNMMI Radiopharmacy and Chemistry
Fig. 5 | EJNMMI Radiopharmacy and Chemistry

Fig. 5

From: Au@109Pd core–shell nanoparticle conjugated to trastuzumab for the therapy of HER2+ cancers: studies on the applicability of 109Pd/109mAg in vivo generator in combined β− auger electron therapy

Fig. 5

Internalization of trastuzumab, Au@Pd-PEG-COOH, and Au@Pd-trastuzumab by SKOV-3 cells determined by confocal microscopy. Fluorescence signals indicate: (green)—subcellular trastuzumab distribution; (blue)—nuclei intracellular localization. Au@Pd-containing particles (dark spots) were visualized with a transmitted light detector (T-PMT). Arrows mark the subcellular localization of the Au@Pd-trastuzumab bioconjugate

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