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EJNMMI Radiopharmacy and Chemistry
Fig. 3 | EJNMMI Radiopharmacy and Chemistry

Fig. 3

From: Imaging of fibrogenesis in the liver by [18F]TZ-Z09591, an Affibody molecule targeting platelet derived growth factor receptor β

Fig. 3

Specificity of [18F]TZ-Z09591 in human liver biopsies. A Representative Sirius red staining, PDGFRβ immunostaining, autoradiography of [18F]TZ-Z09591, and defined region-of-interest (ROIs) images of human liver biopsies of different fibrosis stages. B Correlation of [18F]TZ-Z09591 uptake in human liver cryosections measured by autoradiography with a fibrosis score estimated by Sirius Red staining (r = 0,8334; p < 0.01). C Correlation of [18F]TZ-Z09591 positive area in human liver cryosections measured by autoradiography with the fibrosis score estimated by Sirius Red staining (r = 0,8403; p < 0.01). n = 9. SIR, Sirius red; IHC, immunohistochemistry; ARG, autoradiography; ROI, region-of-interest

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