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EJNMMI Radiopharmacy and Chemistry
Fig. 1 | EJNMMI Radiopharmacy and Chemistry

Fig. 1

From: [225Ac]Ac- and [111In]In-DOTA-trastuzumab theranostic pair: cellular dosimetry and cytotoxicity in vitro and tumour and normal tissue uptake in vivo in NRG mice with HER2-positive human breast cancer xenografts

Fig. 1

a SDS-PAGE of trastuzumab (lane 1) and DOTA-trastuzumab (lane 2) under non-reducing conditions on a 4–20% Mini-Protean Tris/glycine mini-gel. Bands were stained with Coomassie Brilliant Blue G-250. MW: Broad range MW markers. SE-HPLC analysis of b trastuzumab or c DOTA-trastuzumab on a BioSep SEC-S2000 column eluted with 0.1 M NaH2PO4 buffer, pH 7.0 at a flow rate of 0.8 mL/min with UV detection at 280 nm

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