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EJNMMI Radiopharmacy and Chemistry

Table 2 Mean organ absorbed dose calculations using the ICRP 103 model as implemented in IDAC-Dose 2.1

From: First-in-human study of a novel cell death tracer [99mTc]Tc-Duramycin: safety, biodistribution and radiation dosimetry in healthy volunteers

Organs

SPECT analysis

Planar analysis

Adipose/residual tissue

1.76 ± 0.07

1.69 ± 0.10

Adrenals

10.81 ± 1.30

15.88 ± 1.64

Alveolar-interstitial

14.20 ± 1.76

14.25 ± 1.72

Brain

2.48 ± 0.85

2.37 ± 0.87

Breast

2.74 ± 0.24

2.64 ± 0.24

Bronchi bound

8.96 ± 1.24

8.88 ± 1.22

Bronchi sequestered

8.95 ± 1.24

8.88 ± 1.22

Bronchioles

11.04 ± 1.39

11.07 ± 1.35

Colon wall

5.03 ± 0.24

5.46 ± 0.37

Endosteum (bone surface)

4.36 ± 0.78

4.18 ± 0.86

ET region

1.30 ± 0.17

1.03 ± 0.22

ET1 basal cells

0.85 ± 0.12

0.67 ± 0.16

ET2 basal cells

1.30 ± 0.17

1.03 ± 0.22

Eye lenses

0.87 ± 0.13

0.65 ± 0.17

Gallbladder wall

7.98 ± 1.42

10.11 ± 0.97

Heart wall

23.10 ± 7.64

23.35 ± 7.75

Kidneys

19.72 ± 3.42

43.82 ± 4.07

Left colon wall

4.71 ± 0.32

5.13 ± 0.63

Liver

13.83 ± 3.18

15.70 ± 2.33

Lung

11.42 ± 1.38

11.38 ± 1.32

Lymphatic nodes

4.46 ± 0.27

4.66 ± 0.28

Lymph nodes in ET region

1.37 ± 0.31

1.15 ± 0.27

Lymph nodes in sys

4.59 ± 0.29

4.87 ± 0.31

Lymph nodes in thoracic region

6.13 ± 0.90

6.02 ± 0.90

Muscle

2.10 ± 0.18

1.94 ± 0.24

Oesophagus

8.56 ± 1.05

8.60 ± 1.08

Oral mucosa

1.86 ± 0.20

1.53 ± 0.26

Ovaries

6.34 ± 3.23

6.02 ± 3.06

Pancreas

8.54 ± 0.91

10.68 ± 0.73

Pituitary gland

1.81 ± 0.44

1.55 ± 0.48

Prostate

3.81 ± 2.09

3.16 ± 1.81

Recto-sigmoid colon wall

5.20 ± 1.04

4.81 ± 1.08

Red (active) bone marrow

8.49 ± 1.82

8.59 ± 1.82

Right colon wall

5.26 ± 0.40

6.12 ± 0.62

Salivary glands

1.21 ± 0.16

0.90 ± 0.22

Skin

1.62 ± 0.19

1.46 ± 0.23

Small intestine wall

5.80 ± 0.72

6.45 ± 0.69

Spleen

12.37 ± 2.31

14.25 ± 1.67

Stomach wall

8.03 ± 0.88

9.01 ± 0.76

Testes

1.61 ± 0.81

1.08 ± 0.54

Thymus

3.71 ± 0.44

3.44 ± 0.40

Thyroid

3.76 ± 0.35

3.45 ± 0.41

Tongue

1.74 ± 0.20

1.50 ± 0.23

Tonsils

1.38 ± 0.20

1.03 ± 0.23

Ureters

3.84 ± 0.47

4.87 ± 0.41

Urinary bladder wall

8.72 ± 4.25

8.31 ± 4.27

Uterus/cervix

5.67 ± 3.25

5.36 ± 3.07

Effective dose 103 [mSv/MBq]

7.10 ± 0.67

7.61 ± 0.75

  1. For the individual organ doses (expressed in µGy/MBq), the highest dose of either the male or female dose is included in the table. Data are mean ± SD; n = 6
  2. Highest mean organ absorbed doses and effective dose are presented in bold
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