Evaluation of the pharmacokinetics, dosimetry, and therapeutic efficacy for the α-particle-emitting transarterial radioembolization (αTARE) agent [225Ac]Ac-DOTA-TDA-Lipiodol® against hepatic tumors

EJNMMI Radiopharmacy and Chemistry

Table 1 Overview of number (n) of animals (female and male NCG mice, and male Sprague–Dawley rats) used in the biodistribution, survival and relative tumor inhibition rate (RTIR) studies

Mice biodistribution studies
Time-points	35-min	6-h	24-h	72-h	144-h	240-h	504-h
Female mice	n = 3	n = 3	n = 3	n = 3	n = 3	n = 3	n = 3
Male mice	n = 3	n = 3	n = 3	n = 3	n = 3	n = 3	N/A

Rat biodistribution study
Time-points	1-h	24-h	72-h	144-h
Male rats	n = 3	n = 3	n = 2	n = 2

Compound	[²²⁵Ac]Ac-DOTA-TDA-Lipiodol^®	Lipiodol^®	PBS
Mice survival studies
Female mice	n = 8	n = 8	n = 8
Male mice	n = 6	n = 5	n = 5
Mice RTIR studies
Female mice	n = 5	n = 6	n = 6
Male mice	n = 14	n = 11	n = 9