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EJNMMI Radiopharmacy and Chemistry
Fig. 5 | EJNMMI Radiopharmacy and Chemistry

Fig. 5

From: Evaluation of the pharmacokinetics, dosimetry, and therapeutic efficacy for the α-particle-emitting transarterial radioembolization (αTARE) agent [225Ac]Ac-DOTA-TDA-Lipiodol® against hepatic tumors

Fig. 5

Shows the mean absorbed dose coefficient, d (mGy/kBq), for [225Ac]Ac-DOTA-TDA-Lipiodol® in A tumor-bearing male (blue bar) and female (red bar) mice, and B male non-tumor bearing rats (green bar). C The organ/tissue mean absorbed doses using an RBE of 5, DRBE (Gy), and the administered activity based on the calculated estimated maximum tolerable activity (eMTA) in male (blue bar), female (red bar) mice, and male rats (green bar) with liver as the dose limiting organ (maximum tolerable radiation dose (DMAX) of 30 Gy). *Absorbed dose coefficients for organs/tissues in female mice and male rats that includes the free daughters

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