Scheme 1From: Synthesis of a 2-nitroimidazole derivative N-(4-[18F]fluorobenzyl)-2-(2-nitro-1H-imidazol-1-yl)-acetamide ([18 F]FBNA) as PET radiotracer for imaging tumor hypoxiaSynthesis of the labeling precursor 3 and reference compound 4. Reagents and conditions: (a) CH3CO2CH2CH2Br, K2CO3, CH3CN, rt, 21 h; (b) 4.0 N NaOH, H2O/MeOH, rt, 3 h; (c) 4-Fluorobenzylamine, trifluoroacetic acid anhydride, THF, 0 °C, 1 hBack to article page