From: Novel [18F]-labeled thiol for the labeling of Dha- or maleimide-containing biomolecules
Entry | Substratea | Conditionsb | Temperature (°C) | Reaction time (min) | Product | Conversion (%) |
---|---|---|---|---|---|---|
1 | 13 | – | 25 | 45 | [18F]-16 | 0 |
2 | 13 | TCEP, K2CO3 | 25 | 45 | [18F]-16 | 46 |
3 | 13 | TCEP, K2CO3 | 40 | 15 | [18F]-16 | 62 |
4 | 13 | TCEP, K2CO3 | 40 | 45 | [18F]-16 | 97 |
5 | 14 | TCEP, K2CO3 | 50 | 30 | [18F]-17 | 32 |
6 | 14 | TCEP, K2CO3 | 80 | 30 | [18F]-17 | 100 |
7 | 15 | TCEP, K2CO3 | 50 | 45 | [18F]-18 | 0 |
8 | 15 | TCEP, K2CO3 | 80 | 45 | [18F]-18 | 0 |
9 | 20 | TCEP, K2CO3 | 25 | 15 | [18F]-21 | > 95 |
10 | 20 | – | 25 | 15 | [18F]-21 | > 95 |