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Table 2 Results for the 11C-tracer production

From: A new concept for the production of 11C-labelled radiotracers

11C-Tracer N-Methyl-[11C]Choline L-S-Methyl-[11C]Methionine [11C]Acetate
Reaction type Methylation Carboxylation
Time[a] 18 min 19 min 18 ± 2 min
Isolated Yield 900 MBq[b] 3000 MBq[c] 6600 MBq[c]
Yield[d] on [11C]CH3I[e] 85% 42% -
Yield[d] on [11C]CO2 52% 25% 52 ± 5%, (n = 10)
  1. [a]Total reaction time including radioprecursor synthesis: [11C]CH3I (14 min) or [11C]CO2 Bypass (8 min)
  2. [b]Irradiation parameters 20 µA, 2 min ([11C]CO2 A(EOB)cal = 3.7 GBq)
  3. [c]60 µA, 5 min ([11C[CO2 A(EOB)cal = 25 GBq)
  4. [d]Decay corrected at EOB
  5. [e]Gas phase conversion to 11CH3I 60%