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Table 1 Short description and in-process control of a representative [11C]acetate synthesis using a TRACERlab FX FE module

From: A new concept for the production of 11C-labelled radiotracers

Step Duration Description
Pre-synthesis Approximately 30 min before EOB Check valve A (CVA) was closed by helium overpressure from V5. The reactor was filled with MeMgCl THF solution and purged with argon. Finally the [11C]CO2 line was connected
Radiolabelling EOB + 8 min The [11C]CO2 line was positioned close to the product detector (B) so that a temporary increase in activity was observed. After the reaction an activity maximum was measured in the reaction vessel
Quench and wash 2–4 mina The reaction mixture was quenched (Vial 2) and washed with water (Vial 4). The check valves A and B were opened by closing V5 and applying a vacuum to the waste vessel. An increase in activity on the anion exchange cartridge was observed. A pressure increase in the waste vessel indicates that the washing step has been completed
Wash anion exchanger 60 s To ensure that all by-products were separated, the anion exchanger cartridge was washed again with water from V6. A pressure increase in the waste vessel indicates that the washing step has been completed
Helium purge 30 s Further purging with helium closes check valve B (CVB)
Product extraction and degassing 90 s By releasing the overpressure from the product vial, the check valve C (CVC) was opened and the product was extracted from the anion exchanger with saline. The product was transferred into the citrate buffer solution and the by.product [11C]carbonate was removed by helium bubbling
Filling 180 s Filling
  1. aThis step can take from 2 to about 4 min, as the reaction mixture must pass through five ion exchangers