Table 4 Batch information: radioactivity parameters of the automated process
From: Optimised GMP-compliant production of [18F]DPA-714 on the Trasis AllinOne module
Batch information | Batch 1 | Batch 2 | Batch 3 |
|---|---|---|---|
Starting activity [GBq] | 41.82 | 42.38 | 34.49 |
RCY (ndc.) [%] | 42 | 48 | 47 |
RCY (dc.) [%] | 62 | 71 | 70 |
Activity in bulk vial (post-reaction) [GBq] | 17.37 | 20.31 | 16.12 |
Volume in bulk vial (pre-dilution) [mL] | 9.83 | 10.43 | 10.11 |
Volume in bulk (post-dilution) [mL]a | 34.39 | 31.32 | 28.84 |
Activity concentration in bulk vial [MBq/mL] | 505 | 648 | 559 |
Synthesis duration [min]b | 63 | 62 | 64 |