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Table 1 Biodistribution of the MUC1[18F] SFB and MUC1-FA-[18F] SFB hybrid peptide conjugate in normal mice

From: Fast Fluorine-18 labeling and preclinical evaluation of novel Mucin1 and its Folate hybrid peptide conjugate for targeting breast carcinoma

  MUC1[18F]SFB MUC1-FA-[18F]SFB
10 min 60 min 120 min 10 min 60 min 120 min
Blood 9.77 ± 1.02 2.80 ± 0.50 1.34 ± 0.24 3.63 ± 0.24 0.97 ± 0.14 0.39 ± 0.14
Liver 12.10 ± 0.39 2.88 ± 0.66 1.59 ± 0.57 7.17 ± 1.75 2.61 ± 0.69 1.0 ± 0.28
Lung 4.52 ± 0.55 1.34 ± 0.16 0.66 ± 0.12 7.84 ± 1.74 4.19 ± 0.35 1.15 ± 0.51
Kidney 11.42 ± 2.41 3.43 ± 0.45 1.09 ± 0.45 11.09 ± 1.41 5.36 ± 0.50 2.39 ± 0.45
Intestine 3.48 ± 1.01 1.94 ± 0.23 0.65 ± 0.16 4.35 ± 0.91 4.11 ± 0.34 3.29 ± 0.55
Heart 4.77 ± 0.69 1.77 ± 0.24 0.44 ± 0.23 3.57 ± 0.19 1.17 ± 0.24 0.41 ± 0.12
Muscle 1.29 ± 0.09 1.13 ± 0.46 0.69 ± 0.17 2.05 ± 0.45 0.58 ± 0.24 0.15 ± 0.04
Bone 1.34 ± 0.16 1.31 ± 0.28 0.75 ± 0.27 0.20 ± 0.09 0.02 ± 0.01 0.01 ± 0.00
Spleen 2.77 ± 0.25 1.06 ± 0.19 0.24 ± 0.09 2.72 ± 0.65 2.99 ± 0.89 1.96 ± 0.82
  1. The values are average of % injected dose/gram ± SD for n = 4