Table 3 Comparison of the performance of the microscale synthesis reported in this work to literature methods
From: A simple and efficient automated microvolume radiosynthesis of [18F]Florbetaben
Reference | This work | (Zhang et al. 2005) | (Rowe et al. 2008) | (Wang et al. 2011) | (Rominger et al. 2013) | (Patt et al. 2010) | (Collins et al. 2017) | (Brendel et al. 2015) |
|---|---|---|---|---|---|---|---|---|
Number of replicates | n = 3 | NR | NR | n = 4 | NR | n = 10 | n = 3 | NR |
Precursor amount (mg) | 0.052 | 4 | NR | 5 | 5 | NRa | 7 | 5 |
Reaction solvent | DMSO | DMSO | NR | DMSO | MeCN | NRa | MeCN | MeCN |
Reaction volume (mL) | 0.01 | 0.2 | NR | 0.5 | 1 | NRa | 1.8 | 1 |
Formulated productyield (%; d.c.) | 49 ± 3 | 30c | NR | 23 ± 3 | 18 | 7.8 ± 2.6 | 60 ± 9 b | 18 |
Formulation method | SPE (micro C18 cartridge) | NR | SPE (Sep-pak C18) | SPE (Sep-pakplus C18) | SPE (Sep-paklight C18) | SPE (Strata-X 33 μm,reversed phase) | NR | SPE (Sep-pak light C18) |
Synthesis time (min) | 55 | 90c | 60 | 45d | 75 | 50 | 44b | 75 |
Molar activity at EOS(GBq/μmol) | 340 ± 60 | 48–56 | 170 | 25–30 | 80 | 220 ± 170 | NR | 50–90 |