EJNMMI Radiopharmacy and Chemistry

Table 1 Biodistribution of radioactivity in mice after the injection with [¹¹C]1 or [¹¹C]2

From: Radiosynthesis and in vivo evaluation of ¹¹C-labeled BMS-193885 and its desmethyl analog as PET tracers for neuropeptide Y1 receptors

Tissue	Radioactivity level (%ID/g)^a
	5 min^b		15 min^b		30 min^b		60 min^b
	[¹¹C]1	[¹¹C]2	[¹¹C]1	[¹¹C]2	[¹¹C]1	[¹¹C]2	[¹¹C]1	[¹¹C]2
Blood	0.76±0.07	0.65±0.05	0.60±0.06	0.21±0.01	0.50±0.04	0.17±0.02	0.46±0.06	0.19±0.20
Heart	1.93±0.23	0.69±0.09	1.38±0.04	0.42±0.02	1.10±0.05	0.28±0.04	0.82±0.07	0.14±0.04
Lung	5.08±1.12	1.00±0.08	3.43±0.28	0.79±0.11	2.72±0.21	0.82±0.13	2.13±0.36	0.65±0.08
Liver	16.09±1.85	29.54±1.57	8.82±2.28	24.28±3.04	5.05±0.40	15.54±4.41	4.09±1.60	8.43±2.71
Pancreas	3.40±0.46	1.20±0.18	3.75±0.35	1.27±0.11	3.64±0.22	1.18±0.18	3.70±0.41	1.15±0.13
Spleen	3.18±0.67	0.79±0.11	2.05±0.17	0.55±0.07	1.66±0.04	0.37±0.07	1.41±0.24	0.23±0.05
Kidney	17.41±1.12	13.25±1.18	14.06±1.00	10.96±0.51	12.93±1.01	9.89±0.52	13.37±2.72	9.23±1.61
Small intestine	6.98±2.37	15.78±6.51	9.11±1.31	30.77±8.94	11.02±1.44	27.23±12.69	12.43±1.54	13.52±4.25
Muscle	0.64±0.05	0.44±0.21	0.57±0.08	0.30±0.02	0.52±0.11	0.38±0.17	0.47±0.07	0.33±0.19
Brain	0.21±0.01	0.05±0.02	0.40±0.06	0.04±0.04	0.32±0.05	0.01±0.00	0.32±0.05	0.03±0.01

^aMean±S.D. (n=4)
^bTime elapsed after the injection of ¹¹C-labeled tracer

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