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Table 3 Tumor-to-background ratios at different time points after injection of 44Sc/68Ga-labeled DOTA-NOC and NODAGA-NOC

From: 44Sc for labeling of DOTA- and NODAGA-functionalized peptides: preclinical in vitro and in vivo investigations

 

44Sc-DOTA-NOC

68Ga-DOTA-NOC

AR42J

30 min p.i.

2 h p.i.

5 h p.i.

30 min p.i.

2 h p.i.

Tumor-to-blood

3.69 ± 1.52

58.2 ± 6.64

52.0 ± 4.38

5.22 ± 1.07

46.2 ± 2.28

Tumor-to-liver

6.87 ± 2.38

13.1 ± 2.16

15.7 ± 2.82

2.44 ± 0.36

2.22 ± 0.22

Tumor-to-kidney

0.79 ± 0.19

1.01 ± 0.06

0.85 ± 0.04

1.20 ± 0.21

1.41 ± 0.18

 

44Sc-NODAGA-NOC

68Ga-NODAGA-NOC

AR42J

30 min p.i.

2 h p.i.

5 h p.i.

30 min p.i.

2 h p.i.

Tumor-to-blood

5.23 ± 0.22

50.3 ± 16.8

78.6 ± 6.95

4.32 ± 0.58

76.0 ± 4.31

Tumor-to-liver

8.13 ± 0.72

11.9 ± 3.26

11.6 ± 1.51

4.36 ± 0.91

5.88 ± 0.68

Tumor-to-kidney

0.80 ± 0.10

1.22 ± 0.34

0.87 ± 0.24

0.58 ± 0.10

0.85 ± 0.08