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  1. Dopamine receptors are involved in pathophysiology of neuropsychiatric diseases, including Huntington’s disease (HD). PET imaging of dopamine D2 receptors (D2R) in HD patients has demonstrated 40% decrease in ...

    Authors: Tuulia Huhtala, Pekka Poutiainen, Jussi Rytkönen, Kimmo Lehtimäki, Teija Parkkari, Iiris Kasanen, Anu J. Airaksinen, Teija Koivula, Patrick Sweeney, Outi Kontkanen, John Wityak, Celia Dominiquez and Larry C. Park
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:20
  2. Over the years, a broad spectrum of applications of the radionuclide holmium-166 as a medical isotope has been established. The isotope holmium-166 is attractive as it emits high-energy beta radiation which ca...

    Authors: Nienke J. M. Klaassen, Mark J. Arntz, Alexandra Gil Arranja, Joey Roosen and J. Frank W. Nijsen
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:19
  3. The term of neurodegenerative diseases covers a heterogeneous group of disorders that are distinguished by progressive degeneration of the structure and function of the nervous system such as dementias, moveme...

    Authors: Solveig Tiepolt, Marianne Patt, Gayane Aghakhanyan, Philipp M. Meyer, Swen Hesse, Henryk Barthel and Osama Sabri
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:17
  4. Tumors form a complex environment consisting of a variety of non-malignant cells. Especially cancer-associated fibroblasts have been shown to have an important role for different aspects of malignant tumors su...

    Authors: Thomas Lindner, Anastasia Loktev, Frederik Giesel, Clemens Kratochwil, Annette Altmann and Uwe Haberkorn
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:16
  5. Molecular imaging of immune cells might be a potential tool for response prediction, treatment evaluation and patient selection in inflammatory diseases as well as oncology. Targeting interleukin-2 (IL2) recep...

    Authors: Elly L. van der Veen, Inês F. Antunes, Petra Maarsingh, Janet Hessels-Scheper, Rolf Zijlma, Hendrikus H. Boersma, Annelies Jorritsma-Smit, Geke A. P. Hospers, Elisabeth G. E. de Vries, Marjolijn N. Lub-de Hooge and Erik F. J. de Vries
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:15
  6. The β-amyloid radiotracer [11C] PiB is extensively used for the Positron Emission Tomography (PET) diagnosis of Alzheimer’s Disease and related dementias. For clinical use, [11C] PiB is produced using the 11C-met...

    Authors: Pablo Buccino, Eduardo Savio and Williams Porcal
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:14
  7. In this work, a lutetium-177 (177Lu) production method based on the separation of nuclear isomers, 177mLu & 177Lu, is reported. The 177mLu-177Lu separation is performed by combining the use of DOTA & DOTA-labelle...

    Authors: Rupali Bhardwaj, Hubert Th. Wolterbeek, Antonia G. Denkova and Pablo Serra-Crespo
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:13
  8. 161Tb is an interesting radionuclide for cancer treatment, showing similar decay characteristics and chemical behavior to clinically-employed 177Lu. The therapeutic effect of 161Tb, however, may be enhanced due t...

    Authors: Nadezda Gracheva, Cristina Müller, Zeynep Talip, Stephan Heinitz, Ulli Köster, Jan Rijn Zeevaart, Alexander Vögele, Roger Schibli and Nicholas P. van der Meulen
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:12
  9. Many nuclear medicine departments have equipped themselves with automated dispensing systems (ADS) for PET radiopharmaceuticals, in both the operators’ and the patients’ interests. Whether partially or fully a...

    Authors: Tristan Martin, Anaïs Moyon, Cyril Fersing, Evan Terrier, Aude Gouillet, Fabienne Giraud, Benjamin Guillet and Philippe Garrigue
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:11
  10. New regulatory guidance documents from the United States Food and Drug Administration (FDA) and the European Medicines Agency (EMA) have recently been finalized or are in draft format outlining new pathways fo...

    Authors: Sally W. Schwarz and Clemens Decristoforo
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:10
  11. Radiolabeled exendin-4 (Ex4) derivatives are used to target the glucagon-like peptide-1 receptor (GLP-1R) for the clinical diagnosis of insulinomas, a rare type of neuroendocrine tumor. Gallium-68 is an ideal ...

    Authors: Simon A. M. Kaeppeli, Roger Schibli, Thomas L. Mindt and Martin Behe
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:9
  12. Brain PET imaging with different tracers is mainly clinically used in the field of neurodegenerative diseases and brain tumors. In recent years, the potential usefulness of PET has also gained attention in the...

    Authors: Matteo Bauckneht, Selene Capitanio, Stefano Raffa, Luca Roccatagliata, Matteo Pardini, Caterina Lapucci, Cecilia Marini, Gianmario Sambuceti, Matilde Inglese, Paolo Gallo, Diego Cecchin, Flavio Nobili and Silvia Morbelli
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:6
  13. L-Glutamine (L-Gln) is the most abundant amino acid present in the human body and is involved in numerous metabolic pathways. Glutaminolysis is the metabolic process deployed by many aggressive cancers such as...

    Authors: Prashanth K. Padakanti, Shihong Li, Alexander Schmitz, David Mankoff, Robert H. Mach and Hsiaoju S. Lee
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:5
  14. Neuropeptide Y (NPY) has been implicated in a wide variety of physiological processes, including feeding, learning, memory, emotion, cardiovascular homeostasis, hormone secretion, and circadian rhythms. NPY Yl...

    Authors: Kazunori Kawamura, Wakana Mori, Masayuki Fujinaga, Tomoteru Yamasaki, Yiding Zhang, Hidekatsu Wakizaka, Akiko Hatori, Lin Xie, Katsushi Kumata, Takayuki Ohkubo, Yusuke Kurihara, Masanao Ogawa, Nobuki Nengaki and Ming-Rong Zhang
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:4
  15. Clinically applied radiopharmaceuticals have to meet quality release criteria like a high radiochemical yield and radiochemical purity. Many radiopharmaceuticals do not have marketing authorization and have no...

    Authors: Erik de Blois, Rory M. S. de Zanger, Ho Sze Chan, Mark Konijnenberg and Wouter A. P. Breeman
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:3
  16. The histological evaluation of estrogen receptor (ER) and progesterone receptor (PR) expression in breast cancer lesions from biopsy tissue can stratify patients to receive endocrine therapy. Furthermore, PR e...

    Authors: Louis Allott, Cecilia Miranda, Angela Hayes, Florence Raynaud, Christopher Cawthorne and Graham Smith
    Citation: EJNMMI Radiopharmacy and Chemistry 2019 4:1
  17. [11C]Methionine ([11C]MET) acts as an oncological radiopharmaceutical for measuring increased protein synthesis in brain tumours while having low uptake in normal brain an. In several Latin American countries, th...

    Authors: Javier Giglio, Gabriela Rosas, Martín Basso, Andrea Boné, Eduardo Savio and Henry Engler
    Citation: EJNMMI Radiopharmacy and Chemistry 2018 3:15
  18. The free-fatty acid receptor-1 (FFA-1) is expressed by β-cells and is a promising target for molecular imaging of functional β-cell mass. Recently, the ((3-[18F]fluoropropyl)sulfonyl)propoxy-derivative of the hig...

    Authors: Mark H. Dornan, Daniil Petrenyov, José-Mathieu Simard, Antonio Aliaga, Guoming Xiong, Julien Ghislain, Barry Bedell, Vincent Poitout and Jean N. DaSilva
    Citation: EJNMMI Radiopharmacy and Chemistry 2018 3:14
  19. The metadata in the HTML format of these original articles (Eppard et al., 2017; Decristoforo & Patt, 2017; Domnanich et al., 2017; Chan et al., 2017; Jovalekic et al., 2017; Zhang & Villalobos, 2017; Meckel e...

    Authors:
    Citation: EJNMMI Radiopharmacy and Chemistry 2018 3:13

    The original article was published in EJNMMI Radiopharmacy and Chemistry 2016 1:16

    The original article was published in EJNMMI Radiopharmacy and Chemistry 2016 1:15

    The original article was published in EJNMMI Radiopharmacy and Chemistry 2016 1:14

    The original article was published in EJNMMI Radiopharmacy and Chemistry 2016 1:13

    The original article was published in EJNMMI Radiopharmacy and Chemistry 2016 1:12

    The original article was published in EJNMMI Radiopharmacy and Chemistry 2016 1:11

    The original article was published in EJNMMI Radiopharmacy and Chemistry 2016 1:9

    The original article was published in EJNMMI Radiopharmacy and Chemistry 2016 1:8

    The original article was published in EJNMMI Radiopharmacy and Chemistry 2016 1:7

    The original article was published in EJNMMI Radiopharmacy and Chemistry 2016 1:6

    The original article was published in EJNMMI Radiopharmacy and Chemistry 2016 1:5

    The original article was published in EJNMMI Radiopharmacy and Chemistry 2016 1:4

    The original article was published in EJNMMI Radiopharmacy and Chemistry 2016 1:2

    The original article was published in EJNMMI Radiopharmacy and Chemistry 2016 1:3

    The original article was published in EJNMMI Radiopharmacy and Chemistry 2016 1:1

  20. We recently upgraded our [18F]fludeoxyglucose (FDG) production capabilities with the goal of futureproofing our FDG clinical supply, expanding the number of batches of FDG we can manufacture each day, and improvi...

    Authors: Alexandra R Sowa, Isaac M Jackson, Timothy J Desmond, Jeremiah Alicea, Anthony J Mufarreh, Jonathan M Pham, Jenelle Stauff, Wade P Winton, Maria V Fawaz, Bradford D Henderson, Brian G Hockley, Virginia E Rogers, Robert A Koeppe and Peter J H Scott
    Citation: EJNMMI Radiopharmacy and Chemistry 2018 3:12
  21. Several P-glycoprotein (P-gp) substrate tracers are available to assess P-gp function in vivo, but attempts to develop a tracer for measuring expression levels of P-gp have not been successful. Recently, (Z)-2...

    Authors: Joost Verbeek, Jonas Eriksson, Stina Syvänen, Marc Huisman, Robert C. Schuit, Carla F. M. Molthoff, Rob A. Voskuyl, Elizabeth C. de Lange, Adriaan A. Lammertsma and Albert D. Windhorst
    Citation: EJNMMI Radiopharmacy and Chemistry 2018 3:11
  22. To study MMP activity in vivo in disease, several radiolabeled MMP inhibitors functioning as radiotracers have been evaluated by means of SPECT and PET. Unfortunately, most of them suffer from metabolic instab...

    Authors: Verena Hugenberg, Malte Behrends, Stefan Wagner, Sven Hermann, Michael Schäfers, Hartmuth C. Kolb, Katrin Szardenings, Joseph C. Walsh, Luis F. Gomez, Klaus Kopka and Günter Haufe
    Citation: EJNMMI Radiopharmacy and Chemistry 2018 3:10
  23. Targeted radionuclide therapy is a highly efficient but still underused treatment modality for various types of cancers that uses so far mainly readily available β-emitting radionuclides. By using α-particle e...

    Authors: Uwe Holzwarth, Isaac Ojea Jimenez and Luigi Calzolai
    Citation: EJNMMI Radiopharmacy and Chemistry 2018 3:9
  24. [11C]erlotinib has been proposed as a PET tracer to visualize the mutational status of the epidermal growth factor receptor (EGFR) in cancer patients. For clinical use, a stable, reproducible and high-yielding ra...

    Authors: Cécile Philippe, Severin Mairinger, Verena Pichler, Johann Stanek, Lukas Nics, Markus Mitterhauser, Marcus Hacker, Thomas Wanek, Oliver Langer and Wolfgang Wadsak
    Citation: EJNMMI Radiopharmacy and Chemistry 2018 3:8
  25. We recently developed a chelating platform based on the macrocycle 1,4,7-triazacyclononane with up to three, five-membered azaheterocyclic arms for the development of 68Ga- and 64Cu-based radiopharmaceuticals. He...

    Authors: Tilman Läppchen, Jason P. Holland, Yvonne Kiefer and Mark D. Bartholomä
    Citation: EJNMMI Radiopharmacy and Chemistry 2018 3:6
  26. 99mTc-mercaptoacetyl-triglycine (99mTc-MAG3) has been used for dynamic renal imaging since about 30 years. Free pertechnetate (99mTcO4), colloidal 99mTc ((99mTcO2)n), 99mTc-tartrate (precursor), precomplexes (99m

    Authors: Marietta Straub, Michel Leresche, Claude Pilloud, Fabien Devynck, Nicolas Stritt and Rolf Hesselmann
    Citation: EJNMMI Radiopharmacy and Chemistry 2018 3:5
  27. Overexpression of prostatic membrane antigen (PSMA) is associated with the progression and prognosis of prostate cancer. There are numerous studies using this peptide with the 68Ga radionuclide. Previous methods ...

    Authors: Javier Giglio, Maia Zeni, Eduardo Savio and Henry Engler
    Citation: EJNMMI Radiopharmacy and Chemistry 2018 3:4
  28. The global network of cyclotrons has expanded rapidly over the last decade. The bulk of its industrial potential is composed of small medical cyclotrons with a proton energy below 20 MeV for radionuclides prod...

    Authors: Mateusz Adam Synowiecki, Lars Rutger Perk and J. Frank W. Nijsen
    Citation: EJNMMI Radiopharmacy and Chemistry 2018 3:3
  29. Current analytical methods for characterizing pharmacokinetic and metabolic properties of positron emission tomography (PET) and single photon emission computed tomography (SPECT) probes are limited. Alternati...

    Authors: Eszter Boros, Omar R. Pinkhasov and Peter Caravan
    Citation: EJNMMI Radiopharmacy and Chemistry 2018 3:2
  30. Analogues of exendin-4 have been radiolabeled for imaging the glucagon-like peptide type 1 receptors (GLP-1R) which are overexpressed in insulinoma. The aim of this research was to synthesize an 18F–labeled silic...

    Authors: Lukas O. Dialer, Andreas Jodal, Roger Schibli, Simon M. Ametamey and Martin Béhé
    Citation: EJNMMI Radiopharmacy and Chemistry 2018 3:1
  31. Given the increasing exploration of fluorescent tracers in the field of nuclear medicine, a need has risen for practical development guidelines that can help improve the translation aspects of fluorescent trac...

    Authors: Fijs W. B. van Leeuwen, Bart Cornelissen, Federico Caobelli, Laura Evangelista, Latifa Rbah-Vidal, Silvana Del Vecchio, Catarina Xavier, Jacques Barbet and Marion de Jong
    Citation: EJNMMI Radiopharmacy and Chemistry 2017 2:15
  32. The favorable decay properties of 43Sc and 44Sc for PET make them promising candidates for future applications in nuclear medicine. An advantage 43Sc (T1/2 = 3.89 h, Eβ+ av = 476 keV [8...

    Authors: Katharina A. Domnanich, Robert Eichler, Cristina Müller, Sara Jordi, Vera Yakusheva, Saverio Braccini, Martin Behe, Roger Schibli, Andreas Türler and Nicholas P. van der Meulen
    Citation: EJNMMI Radiopharmacy and Chemistry 2017 2:14
  33. Carbon-11 labeled L-methionine (11C–MET) is a popular tracer used in the clinic for imaging brain tumors with positron emission tomography. However, the stability of 11C–MET in its final formulation is not well d...

    Authors: Michael Woods, Leo Leung, Kari Frantzen, Jennifer G. Garrick, Zhengxing Zhang, Chengcheng Zhang, Wade English, Don Wilson, François Bénard and Kuo-Shyan Lin
    Citation: EJNMMI Radiopharmacy and Chemistry 2017 2:13
  34. The EU regulation 536/2014 aims to facilitate the experimental use of diagnostic radiopharmaceuticals in particular for GMP requirements and needs to be applied in EU countries. As definitely clarified by this...

    Authors: G. Bormans, A. Buck, A. Chiti, M. Cooper, J. Croasdale, M. Desruet, V. Kumar, Y. Liu, I. Penuelas, C. Rossetti, R. Schiavo, S. W. Schwarz and A. D. Windhorst
    Citation: EJNMMI Radiopharmacy and Chemistry 2017 2:12
  35. The synthesis of [11C]L-deprenyl-D2 for imaging of astrocytosis with positron emission tomography (PET) in neurodegenerative diseases has been previously reported. [11C]L-deprenyl-D2 radiosynthesis requires a pre...

    Authors: Kevin Zirbesegger, Pablo Buccino, Ingrid Kreimerman, Henry Engler, Williams Porcal and Eduardo Savio
    Citation: EJNMMI Radiopharmacy and Chemistry 2017 2:10
  36. The importance of the sulfur-fluorine bond is starting to increase in modern medicinal chemistry literature. This is due to a better understanding of the stability and reactivity of this moiety depending on th...

    Authors: Giancarlo Pascali, Lidia Matesic, Bo Zhang, Andrew T. King, Andrea J. Robinson, Alison T. Ung and Benjamin H. Fraser
    Citation: EJNMMI Radiopharmacy and Chemistry 2017 2:9
  37. Validation and qualification activities are nowadays an integral part of the day by day routine work in a radiopharmacy. This document is meant as an Appendix of Part B of the EANM “Guidelines on Good Radiopha...

    Authors: S. Todde, P. Kolenc Peitl, P. Elsinga, J. Koziorowski, V. Ferrari, E. M. Ocak, O. Hjelstuen, M. Patt, T. L. Mindt and M. Behe
    Citation: EJNMMI Radiopharmacy and Chemistry 2017 2:8
  38. [18F]AV1451 is a commonly used radiotracer for imaging tau deposits in Alzheimer’s disease (AD) and related non-AD tauopathies. Existing radiosyntheses of [18F]AV1451 require complex purifications to provide dose...

    Authors: Andrew V. Mossine, Allen F. Brooks, Bradford D. Henderson, Brian G. Hockley, Kirk A. Frey and Peter J. H. Scott
    Citation: EJNMMI Radiopharmacy and Chemistry 2017 2:7
  39. Oncological pretargeting has been implemented and tested in several different ways in preclinical models and clinical trials over more than 30 years. Despite highly promising results, pretargeting has not achi...

    Authors: Clément Bailly, Caroline Bodet-Milin, Caroline Rousseau, Alain Faivre-Chauvet, Françoise Kraeber-Bodéré and Jacques Barbet
    Citation: EJNMMI Radiopharmacy and Chemistry 2017 2:6
  40. Radiotheragnostics makes use of the same molecular targeting vectors, labeled either with a diagnostic or therapeutic radionuclide, ideally of the same chemical element. The matched pair of scandium radionucli...

    Authors: Katharina A. Domnanich, Cristina Müller, Martina Benešová, Rugard Dressler, Stephanie Haller, Ulli Köster, Bernard Ponsard, Roger Schibli, Andreas Türler and Nicholas P. van der Meulen
    Citation: EJNMMI Radiopharmacy and Chemistry 2017 2:5
  41. The somatostatin receptor subtype 2 (sstr2) is expressed on a majority of luminal breast cancers, however SPECT and scintigraphy imaging with agonistic sstr2 probes has been sub-optimal. High affinity antagoni...

    Authors: Iulia Dude, Zhengxing Zhang, Julie Rousseau, Navjit Hundal-Jabal, Nadine Colpo, Helen Merkens, Kuo-Shyan Lin and François Bénard
    Citation: EJNMMI Radiopharmacy and Chemistry 2017 2:4
  42. Radiolabeled phosphatidylserine (PS)-binding peptides represent an innovative strategy for molecular imaging of apoptosis and thrombus. The hexapeptide PGDLSR was described as a selective and high affinity lig...

    Authors: Rana Ben Azzouna, Alexandre Guez, Khadija Benali, Faisal Al-Shoukr, Walter Gonzalez, Philippe Karoyan, François Rouzet and Dominique Le Guludec
    Citation: EJNMMI Radiopharmacy and Chemistry 2017 2:3
  43. The chemokine receptor 4 (CXCR4) is an important molecular target for both visualization and therapy of tumors. The aim of the present study was the synthesis and preclinical evaluation of a 64Cu-labeled, CXCR4-t...

    Authors: Andreas Poschenrieder, Margret Schottelius, Theresa Osl, Markus Schwaiger and Hans-Jürgen Wester
    Citation: EJNMMI Radiopharmacy and Chemistry 2017 2:2

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