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Table 1 Summary of the [18F]TFB production development studies

From: High molar activity [18F]tetrafluoroborate synthesis for sodium iodide symporter imaging by PET

Synthesizer

Solvent

Dilution

Activity at EOB (STD) (GBq)

RCY (CV) (%)

RCP (STD) (%)

Am (range) at EOS (GBq/µmol)

Am normalised to activity at SOS (µmol−1)

Precursor: BF3*MeOH (10%)

 SYNTHRA (n = 4)

CH3CN

1/600

103 (21)

24 (17)

98.8 (0.7)

90 (32–168)

0.9

 SYNTHRA (n = 9)*

CH3CN

1/500

52 (11)

41 (18)

98.4 (1.5)

78 (34–217)

1.4

 SYNTHRA (n = 9)

CH3OH

1/100

15 (14)

29 (24)

98.5 (1.5)

19.8 (6–96)

1.32

 SYNTHRA (n = 5)

CH3OH

1/50

65(15)

35(17)

97.6 (0.9)

15 (0.9–27)

0.23

Precursor: BF3*CH3CN (15.2–16.8%)

 SYNTHRA (n = 9)

CH3CN

1/250

6(5)

55 (36)

98 (3)

5.6 (2.5–23)

0.93

 FXFN (n = 5)

CH3CN

1/300

35 (30)

50(26)

98 (1)

39.8 (2.1–99.3)

1.13

Precursor: BF3*2H2O (96%)

 FXFN (n = 2)

CH3OH

1/3000

48

26

99.2

54 (4.7–55.3)

0.62

Published results for comparison

 Jiang et al. (2016)

  

42 (2)

20 (0.7)

98

8.8 (0.6)

0.21

 Khoshnevisan et al. (2016)

  

1.5

13.2 (5.9)

 

5.7 (3.5)

3.8

 O'Doherty et al. (2017)

  

46 (6)

 

99.8

2.6 (1.4)

0.05

 Jiang and DeGrado (2018)

  

15 (3)

10

96

1.1

0.07

  1. *Conditions of choice for the optimised radiosynthesis procedure
  2. CV Coefficient varation