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EJNMMI Radiopharmacy and Chemistry

Table 2 Comparison of semi-automated small SPE column product to HPIC product[a]

From: A simple and automated method for 161Tb purification and ICP-MS analysis of 161Tb

 

Mass (ng) [% of Total Mass[b]]

Average 161Tb Recovery (%)

Method

161Tb[c]

159Tb[c]

160Gd

161Dy

HPIC (n = 1)

17.5 ng

[91.7%]

1.4 ng

[7.2%]

0.2 ng

[0.9%]

 < 0.1 ng

[< 0.2%]

NA

Semi-Automated Small Column (n = 3)

17.5 ng

[45.5 ± 3.9%]

6.1 ± 1.3 ng

[15.8 ± 3.5%]

13.2 ± 3.5 ng

[34.4 ± 9.2%]

1.6 ± 2.8 ng

[4.3 ± 7.4%]

77 ± 13

  1. [a]Semi-automated small column purification was performed on three portions (50 MBq, 50 MBq, and 110 MBq) split from a single batch and the results expressed as average ± standard deviation. HPIC purification was performed with the same batch material. All results decay corrected to EOS from each purification and normalized to 75 MBq 161Tb. All samples measured by ICP-MS. [b]Total Mass defined as the sum of (161Tb + 159Tb + 160Gd + 161Dy). [c]The small column purified 161Tb was purified > 1 week after the HPIC purified thus accounting for the lower 161Tb/159Tb ratio
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