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EJNMMI Radiopharmacy and Chemistry

Table 2 Downscaled reaction conditions, based upon literature

From: Radiolabeling and quality control of therapeutic radiopharmaceuticals: optimization, clinical implementation and comparison of radio-TLC/HPLC analysis, demonstrated by [177Lu]Lu-PSMA

Reaction components

Condition A: amount/final concentration

During labelling

[177Lu]LuCl3

74 MBq

PSMA-I&T (0.1 M acetic acid)

1 µg

Gentisic acid

2 mM

Ascorbic acid

7 mM

Directly after labelling

DTPA

2.5 mM

Final volume

40 μL

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