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EJNMMI Radiopharmacy and Chemistry

Table 5 Yields of [18F]FEOH, [18F]VF and [18F]FEtOTs determined by radio-HPLC analysis of the crude product, obtained at different temperature, time and the base/precursor molar ratio

From: A closer look at the synthesis of 2-[18F]fluoroethyl tosylate to minimize the formation of volatile side-products

Entry

T (°C)

t (min)

K2CO3 (mg)

Base/precursor

(Molar ratio)

[18F]FEOH

(%)

[18F]VF

(%)

[18F]FEtOTs

(%)

[18F]VF/[18F]FEOH

1

130

15

2

0.7

10 ± 2

29 ± 2

59 ± 2

2.9

2

130

15

5

1.7

19 ± 4

12 ± 4

65 ± 4

0.6

3

100

1

2

0.7

3 ± 1

6 ± 2

80 ± 4

2

4

100

1

5

1.7

3 ± 1

2 ± 1

91 ± 1

0.7

  1. Experiments were performed in triplicates
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