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EJNMMI Radiopharmacy and Chemistry
Fig. 4 | EJNMMI Radiopharmacy and Chemistry

Fig. 4

From: A closer look at the synthesis of 2-[18F]fluoroethyl tosylate to minimize the formation of volatile side-products

Fig. 4

Radiochromatograms of crude mixtures of [18F]FEtOTs at two different conditions of time, temperature, and molar ratio of base to precursor. a: 130 °C—15 min—0.7. b: 100 °C—1 min—0.7. c: 130 °C—15 min—1.7. d: 100 °C—1 min—1.7. The retention times of [18F]FEOH and [18F]VF were 2.7 and 4.7 min, respectively. The retention time of the cold reference FEtOTs was 8.7 min. HPLC chromatograms are representative of (n = 3) and were performed using an Agilent Zorbax Eclipse Plus C18 (5 µm, 4.6 × 250 mm) analytical column; elution with 0.1% TFA water / MeCN, 55:45 at 1 mL/min; monitored with a radioactivity detector

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