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EJNMMI Radiopharmacy and Chemistry
Fig. 3 | EJNMMI Radiopharmacy and Chemistry

Fig. 3

From: A closer look at the synthesis of 2-[18F]fluoroethyl tosylate to minimize the formation of volatile side-products

Fig. 3

HS-GC–MS analysis of the cold FEtOTs crude reaction mixture. a [18F]FEtOTs and FEtOTs crude mixtures were co-injected and analyzed in an analytical HPLC using an Agilent Zorbax Eclipse Plus C18 (5 µm, 4.6 × 250 mm) analytical column; elution with 0.1% TFA water / MeCN, 55:45 at 1 mL/min; and monitored with a radioactivity detector. Fractions collected at 2.7 min and 4.7 min observed in the radio-HPLC chromatogram were frozen at − 20 °C until further analysis. b Samples were defrosted and heated at 80ºC, and 3 mL of gas was extracted from each collected sample. c Samples were analyzed by HS-GC–MS. Analysis showed the characteristic m/z ratios 31 and 64 corresponding to 2-fluoroethanol ([19F]FEOH), and m/z ratios 46 for vinyl fluoride ([19F]VF)

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