Automated synthesis of [68Ga]Ga-FAPI-46 without pre-purification of the generator eluate on three common synthesis modules and two generator types

EJNMMI Radiopharmacy and Chemistry

Table 3 Radiochemical purity and yield of [⁶⁸Ga]Ga-FAPI-46

Modules	Generator	Buffer	Radio chemical purity	Radio chemical yield
Trasis	GalliaPharm	Acetate	99.4%	92.45%
Scintomics	iThemba	HEPES	99.7%	93.3%
Synthra	GalliaPharm	HEPES	99.8%	92.86%

Legend: Syntheses conducted using the cassette and chemistry kit for labeling PSMA-11 with.⁶⁸ Ga at 90 °C and 4 min with 300 µg Ascorbic acid added to the buffer system (n = 3)