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EJNMMI Radiopharmacy and Chemistry
Fig. 6 | EJNMMI Radiopharmacy and Chemistry

Fig. 6

From: Synthesis of a 2-nitroimidazole derivative N-(4-[18F]fluorobenzyl)-2-(2-nitro-1H-imidazol-1-yl)-acetamide ([18 F]FBNA) as PET radiotracer for imaging tumor hypoxia

Fig. 6

In vitro uptake assay. AGS and MKN45 cells were seeded in a 6-well plate and cultured for 48 h under normoxic (21% O2) or hypoxic (1% of O2) for 48 h. After this period, 0.37 MBq of (A) [18F]FBNA or (B) [18F]FAZA was incubated for 1 h. Bars show the mean ± standard deviation (SD) of the uptake of the radiotracer (cpm)/2 × 105 cells of three independent experiments (n = 3). Data were analyzed by one unpaired t-test (multiple t tests); *p < 0.5, ****p < 0.0001 (Holm-Sidak method)

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