Table 1 Summary of potential PET tracers for TAMs, evaluated in preclinical or clinical studies
From: Potential PET tracers for imaging of tumor-associated macrophages
Target | Macrophage phenotype | Radiotracer | Species | Disease (model) | References |
|---|---|---|---|---|---|
CD206 | M2 | [18F]FDM | Rabbit | Atherosclerosis model | Tahara et al. (2014) |
[18F]FB-anti-MMR-sdAb | Mouse | Lung cancer xenograft model | Blykers et al. (2015) | ||
[68Ga]NOTA-MSA | Mouse | Atherosclerosis model | Kim et al. (2016) | ||
[68Ga]NOTA-anti-MMR-Nb | Mouse | Atherosclerosis model | Varasteh et al. (2019) | ||
[68Ga]Ga-NOTA-anti-MMR-sdAb | Mouse | Lung cancer xenograft model | Xavier et al. (2019) | ||
CD163 | M2 | [68Ga]ED2 | Rat | Arthritis model | Eichendorff et al. (2015) |
Arginase | M2 | [18F]FMARS | Mouse | Prostate cancer xenograft model | Clemente et al. (2021) |
[18F]FBMARS | Mouse | Prostate cancer xenograft model | Clemente et al. (2021) | ||
CSF-1R | M1 and M2 | [11C]AZ683 | Rat, non-human primate | Healthy | Tanzey et al. (2018) |
[11C]CPPC | Mouse, non-human primate | Neuroinflammation model (LPS) | |||
[11C]GW2580 | Mouse, non-human primate | Neuroinflammation mouse model (LPS) and health non-human primates | Zhou et al. (2021) | ||
CD68 | M1 and M2 | [64Cu]CD68-Fc | Mouse | Atherosclerosis model | Bigalke et al. (2014) |
CCR2 | M1 and M2 | [64Cu]-DOTA-ECLi | Rat | Abdominal aortic aneurysm model | English et al. (2020) |
[64Cu]Cu@CuOx-ECLi | Mouse | Pancreatic ductal adenocarcinoma model | Zhang et al. (2021) | ||
[18F]6b | Mouse | Healthy | Wagner et al. (2021) | ||
Folate receptor | M1 and M2 | [68Ga]NOTA-folate | Mouse | KB xenograft model | Brand et al. (2017) |
[18F]AlF-NOTA-folate-PEG12 | Mouse | KB xenograft model | Chen et al. (2017) | ||
[18F]fluoro-PEG-folate | Mouse | Rheumatoid arthritis model | Chandrupatla et al. (2018) | ||
Human | Rheumatoid arthritis | Verweij et al. (2020) | |||
[18F]AlF-NOTA-folate | Mouse | Atherosclerosis model | Silvola et al. (2018) | ||
[18F]AzaFol | Mouse | Lung fibrosis model | Schniering et al. (2019) | ||
| Â | Â | Human | Ovarian and lung cancer |