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EJNMMI Radiopharmacy and Chemistry

Table 2 Results for the 11C-tracer production

From: A new concept for the production of 11C-labelled radiotracers

11C-Tracer

N-Methyl-[11C]Choline

L-S-Methyl-[11C]Methionine

[11C]Acetate

Reaction type

Methylation

Carboxylation

Time[a]

18 min

19 min

18 ± 2 min

Isolated Yield

900 MBq[b]

3000 MBq[c]

6600 MBq[c]

Yield[d] on [11C]CH3I[e]

85%

42%

-

Yield[d] on [11C]CO2

52%

25%

52 ± 5%, (n = 10)

  1. [a]Total reaction time including radioprecursor synthesis: [11C]CH3I (14 min) or [11C]CO2 Bypass (8 min)
  2. [b]Irradiation parameters 20 µA, 2 min ([11C]CO2 A(EOB)cal = 3.7 GBq)
  3. [c]60 µA, 5 min ([11C[CO2 A(EOB)cal = 25 GBq)
  4. [d]Decay corrected at EOB
  5. [e]Gas phase conversion to 11CH3I 60%
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