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EJNMMI Radiopharmacy and Chemistry

Table 1 Biodistribution of [11C]PK68 in mice (n = 3, mean ± SD)

From: Synthesis of [11C]carbonyl-labeled cyclohexyl (5-(2-acetamidobenzo[d]thiazol-6-yl)-2-methylpyridin-3-yl)carbamate ([11C-carbonyl]PK68) as a potential PET tracer for receptor-interacting protein 1 kinase

Tissue

Time after the injection (min)

1

5

15

30

60

Blood

2.4 ± 0.3

1.3 ± 0.2

1.1 ± 0.1

0.8 ± 0.1

0.5 ± 0.1

Heart

7.6 ± 0.3

2.8 ± 0.3

2.1 ± 0.3

1.3 ± 0.1

0.7 ± 0.1

Lung

5.2 ± 0.2

2.6 ± 0.2

2.1 ± 0.3

1.5 ± 0.2

0.8 ± 0.1

Liver

8.0 ± 0.8

17.2 ± 0.7

15.6 ± 0.8

10.7 ± 0.3

6.0 ± 0.2

Pancreas

3.4 ± 0.2

2.7 ± 0.3

2.1 ± 0.3

1.4 ± 0.1

0.8 ± 0.1

Spleen

1.5 ± 0.2

1.6 ± 0.1

1.4 ± 0.2

0.9 ± 0.0

0.5 ± 0.1

Kidney

10.3 ± 0.5

9.9 ± 0.4

7.7 ± 1.0

6.2 ± 0.6

3.2 ± 0.1

Adrenals

6.2 ± 2.7

4.0 ± 0.5

3.3 ± 0.5

2.1 ± 0.8

1.2 ± 0.1

Stomach

1.2 ± 0.2

2.0 ± 0.1

4.0 ± 1.2

4.7 ± 1.0

7.2 ± 2.4

Small intestine

1.8 ± 0.1

3.3 ± 0.1

9.8 ± 3.1

16.7 ± 1.4

27.7 ± 3.0

Large intestine

0.7 ± 0.1

0.9 ± 0.1

1.4 ± 0.3

1.7 ± 0.4

2.6 ± 0.6

Testis

0.3 ± 0.1

0.3 ± 0.0

0.3 ± 0.0

0.3 ± 0.0

0.2 ± 0.0

Muscle

1.9 ± 0.3

1.1 ± 0.1

0.8 ± 0.1

0.6 ± 0.1

0.3 ± 0.0

Brain

0.6 ± 0.0

0.4 ± 0.0

0.3 ± 0.0

0.2 ± 0.0

0.1 ± 0.0

  1. Radioactivity is expressed as %ID/g
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