Table 3 Overview of stability studies with activity investigated, temperature, amount of ethanol, quality references and shelf life.
Study | Activity GBq/mL | Temperature | Ethanol (%) | Quality references | Shelf life |
|---|---|---|---|---|---|
Ferreira et al. (2009) | 0.3–0.7 | RT (22 °C) | ≈ 0.04 | USP 31 | 10 h |
Walters et al. (2011) | 19.7–22.6 EOS | – | 0.2 | USP 34 | 12 h |
Dantas et al. (2013) | 0.7–4.8 | 5, 25, 40 °C | 0.1-0.4 | Ph. Eur. 7ed | 16 h |
Rahmani et al. (2017) | 0.3–0.5 | 18–23 °C, 35–40 °C | 0.012 mg/mL | Ph. Eur. 7ed | 10 h |
Jószai et al. (2019) | 2 and 15 | RT | 50 mmol/L | Ph. Eur. 9ed | 210 min or 15 h |
Kiselev et al. (2006) | – | – | min. 0.01%/GBq/mL | – | – |
Fawdry (2007) | 6.3 and 11.5 | RT | 0.1 | BP 2005 | 14 h |
Jacobson et al. (2009) | up to 14.2 | – | 0.1 | Ph. Eur. 6ed | 10 h |
Rensch et al. (2012) | 4–23 | – | – | – | 14 h |
Long et al. (2013) | 2.26–8.8 | – | 0.2 ± 0.07 | USP 34 | – |