Fig. 4

Examples displaying the connection of molar activity, PET image quality and pharmaceutical dose. (left) [¹¹C]mHED, requires high A_m for sufficient quality of the PET scan. Before a pharmacological dose is reached the image quality is affected. (middle) [¹¹C]PHNO requires high A_m for patient application and safety. At first a pharmacological effect, like nausea, is observed before the quality of the PET image is influenced. The release criteria has to be strictly followed for this kind of compounds to avoid any side or toxic effects. (right) [¹¹¹In]J591 is reported to have a low lesion to non-lesion residence time if the molar activity is high. Higher amounts of non-labelled autologue increases the residence time and subsequently the quality of the image