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EJNMMI Radiopharmacy and Chemistry
Fig. 8 | EJNMMI Radiopharmacy and Chemistry

Fig. 8

From: Closing the gap between 19F and 18F chemistry

Fig. 8

A Radiosynthesis of [18F]difluoromethylarenes via oxidative decarboxylation with Selectfluor bis(triflate). B Radiosynthesis of [18F]difluoromethylarenes via halogen exchange. C Two-step approach from aryl (pseudo) halides. D Two-step approach from benzyl bromides. E Two-step approach from aryl boronic acids. F New disconnection: late-stage radical 18F-difluoromethylation with Hu-type [18F]reagent. EWG = electron-withdrawing group. EDG = electron-donating group

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