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Fig. 7 | EJNMMI Radiopharmacy and Chemistry

Fig. 7

From: Closing the gap between 19F and 18F chemistry

Fig. 7

A Halogen exchange strategy for [18F]CF3 construction. B Silver-mediated halogen exchange for -CF3, -OCF3, -SCF3, -CF2H, -OCF2H 18F-radiofluorination. C Radiosynthesis of [18F]TFMISO. D 18F-Functionalization of fluoroalkenes, E Radiofluorination of trifluoroacetamides. F Oxidative 18F-fluorodesulfurisation. G Radiosynthesis of [18F]EF5 from [18F]F2. H Decarboxylative radiofluorination for the synthesis of [18F]CF3. I Ar–[18F]CF3 disconnection: 18F-Trifluoromethylation of aryl iodides and aryl boronic acids. J [18F]Trifluoroethanol for cross-coupling reaction. K Manganese-mediated [18F]CF3 construction. L Radiosynthesis of the [18F]Me3SiCF3 ([18F]Ruppert-Prakash reagent. M New disconnection: Aliphatic 18F-trifluoromethylation from C–18F reductive elimination from AuIII center. EWG = electron-withdrawing group. EDG = electron-donating group

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