Radiation equivalent dose (Sv/MBq) | ||||
---|---|---|---|---|
Organ | [64Cu]Cu-DOTA-panitumumab F(ab´)2 b | [177Lu]Lu-DOTA-panitumumab F(ab´)2 c | [177Lu]Lu-DOTA-panitumumab F(ab´)2 d | Comparison of doses for 177Lu calculated from 64Cu vs. 177Lu biodistribution (BOD) (P-value) |
Heart | 0.03 ± 0.01 | 0.35 ± 0.06 | 0.32 ± 0.13 | n.s. |
Lungs | 0.05 ± 0.01 | 0.51 ± 0.05 | 0.38 ± 0.04 | n.s. |
Liver | 0.10 ± 0.02 | 1.22 ± 0.13 | 1.82 ± 0.14 | 0.03 |
Spleen | 0.04 ± 0.01 | 0.71 ± 0.20 | 0.66 ± 0.18 | n.s. |
Pancreas | 0.02 ± 0.01 | 0.26 ± 0.08 | 0.16 ± 0.04 | n.s. |
Stomach | 0.03 ± 0.01 | 0.33 ± 0.03 | 0.27 ± 0.04 | n.s. |
Intestines | 0.02 ± 0.00 | 0.31 ± 0.05 | 0.21 ± 0.05 | n.s. |
Kidneys | 0.07 ± 0.01 | 0.63 ± 0.09 | 0.75 ± 0.08 | n.s. |
Tumour e | 0.14 ± 0.03 | 2.00 ± 0.60 | 2.50 ± 0.80 | n.s. |
Whole Body | 0.05 ± 0.00 | 0.26 ± 0.02 | 0.34 ± 0.02 | 0.05 |