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EJNMMI Radiopharmacy and Chemistry
Fig. 4 | EJNMMI Radiopharmacy and Chemistry

Fig. 4

From: Dose predictions for [177Lu]Lu-DOTA-panitumumab F(ab′)2 in NRG mice with HNSCC patient-derived tumour xenografts based on [64Cu]Cu-DOTA-panitumumab F(ab′)2 – implications for a PET theranostic strategy

Fig. 4

Posterior whole-body coronal microSPECT/CT images of a NRG mouse bearing s.c. implanted HNSCC PDX at a. 6 h, b. 24 h or c. 48 h p.i. of [177Lu]Lu-DOTA-panitumumab F(ab´)2 or d. 24 h p.i. of irrelevant [177Lu]Lu-DOTA-trastuzumab F(ab´)2. The tumour is shown by the white arrow. At 6 h p.i., the mediastinum (blood pool; white arrowhead), liver (blue arrowhead) and kidneys (broken white circles) were visualized, while at 24 and 48 h p.i., the liver and kidneys were the main normal organs visualized. e. Immunohistochemical staining of the excised tumour demonstrated very low HER2 expression

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