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Table 1 Average values of selected production and QC parameters for batches of [18F]1 produced at the three different productions sites. Errors indicate standard deviations of the mean. The value for the enantiomeric purity at HUH includes productions where the alkylation is carried out at − 20 °C and at room temperature (rt)

From: GMP production of 6-[18F]Fluoro-l-DOPA for PET/CT imaging by different synthetic routes: a three center experience

  AUH OUH HUH
non-d.c. RCY 9.3 ± 4.2% 5.6 ± 0.3% 30 ± 8%
Radiochemical purity 97.4 ± 1.4% 98.4 ± 0.16% 99.8 ± 0.5%
[18F]F 1.06 ± 0.84% 0.74 ± 0.1% ~ 0.2%a
Enantiomeric purity (l-isomer) 99.4 ± 0.2% 99.9 ± 0.06% 98.6 ± 0.4% (− 20 °C)
96.7 ± 0.8% (rt)
Molar activity 52 ± 15 MBq/μmol 236 ± 28 GBq/μmol 189 ± 56 GBq/μmol
[19F]1 1.42 ± 0.68 mg/ml 0.32 ± 0.056 μg/ml 0.60 ± 0.13 μg/ml
6-OH-DOPA 3.84 ± 1.6 μg/ml 3.6 ± 0.18 μg/ml Not detected
  1. aThe standard deviation of the mean is larger than the mean itself, making the value statistically insignificant