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Scheme 1 | EJNMMI Radiopharmacy and Chemistry

Scheme 1

From: GMP production of 6-[18F]Fluoro-l-DOPA for PET/CT imaging by different synthetic routes: a three center experience

Scheme 1

The three different synthetic pathways to [18F]1 discussed in the present work. i, [18F]F2, CHCl3, RT; ii, 57% HI, 150 °C; iii, [18F]TBAF, DMSO, 110 °C; iv, m-CPBA, MeCN, 55 °C; v, 30% HCl, EtOH, 50 °C; vi, [18F]KF/K222, DMF, 165 °C; vii, NaBH4, H2O @ tC18, RT; viii, 57% HI @ tC18, RT; ix, Ph2C=NCH2Boc, DCM, cPTC, KOH, − 20 °C; x, 57% HI, 165 °C.

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