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Table 2 Biodistribution of the MUC1-[18F] SFB and MUC1-FA-[18F] SFB hybrid peptide conjugates in tumor-bearing SCID mice

From: Fast Fluorine-18 labeling and preclinical evaluation of novel Mucin1 and its Folate hybrid peptide conjugate for targeting breast carcinoma

 

MUC1-[18F]SFB

MUC1-FA-[18F]SFB

60 min

60 min

blocked

60 min

60 min

blocked

Blood

0.35 ± 0.11

0.39 ± 0.15

0.67 ± 0.07

0.52 ± 0.05

Liver

0.85 ± 0.07

0.55 ± 0.17

3.20 ± 0.36

2.14 ± 0.13

Lung

1.39 ± 0.42

0.99 ± 0.22

2.96 ± 0.40

2.05 ± 0.49

Kidney

1.28 ± 0.03

1.20 ± 0.23

5.14 ± 0.53

1.86 ± 0.61

Intestine

0.21 ± 0.01

0.19 ± 0.08

4.36 ± 0.77

2.50 ± 0.65

Heart

0.38 ± 0.03

0.31 ± 0.07

1.98 ± 0.11

1.71 ± 0.12

Muscle

0.22 ± 0.13

0.24 ± 0.09

0.61 ± 0.05

0.25 ± 00.09

Bone

0.11 ± 0.01

0.15 ± 0.03

0.70 ± 0.14

0.30 ± 0.21

Spleen

1.07 ± 0.26

0.88 ± 0.11

2.95 ± 0.37

2.28 ± 0.71

Tumor

2.93 ± 0.12

1.61 ± 0.22

12.03 ± 0.57

1.37 ± 0.22

  1. The values are average of % injected dose/gram ± SD for n = 4