Skip to main content

Table 1 Biodistribution of the MUC1[18F] SFB and MUC1-FA-[18F] SFB hybrid peptide conjugate in normal mice

From: Fast Fluorine-18 labeling and preclinical evaluation of novel Mucin1 and its Folate hybrid peptide conjugate for targeting breast carcinoma

 

MUC1[18F]SFB

MUC1-FA-[18F]SFB

10 min

60 min

120 min

10 min

60 min

120 min

Blood

9.77 ± 1.02

2.80 ± 0.50

1.34 ± 0.24

3.63 ± 0.24

0.97 ± 0.14

0.39 ± 0.14

Liver

12.10 ± 0.39

2.88 ± 0.66

1.59 ± 0.57

7.17 ± 1.75

2.61 ± 0.69

1.0 ± 0.28

Lung

4.52 ± 0.55

1.34 ± 0.16

0.66 ± 0.12

7.84 ± 1.74

4.19 ± 0.35

1.15 ± 0.51

Kidney

11.42 ± 2.41

3.43 ± 0.45

1.09 ± 0.45

11.09 ± 1.41

5.36 ± 0.50

2.39 ± 0.45

Intestine

3.48 ± 1.01

1.94 ± 0.23

0.65 ± 0.16

4.35 ± 0.91

4.11 ± 0.34

3.29 ± 0.55

Heart

4.77 ± 0.69

1.77 ± 0.24

0.44 ± 0.23

3.57 ± 0.19

1.17 ± 0.24

0.41 ± 0.12

Muscle

1.29 ± 0.09

1.13 ± 0.46

0.69 ± 0.17

2.05 ± 0.45

0.58 ± 0.24

0.15 ± 0.04

Bone

1.34 ± 0.16

1.31 ± 0.28

0.75 ± 0.27

0.20 ± 0.09

0.02 ± 0.01

0.01 ± 0.00

Spleen

2.77 ± 0.25

1.06 ± 0.19

0.24 ± 0.09

2.72 ± 0.65

2.99 ± 0.89

1.96 ± 0.82

  1. The values are average of % injected dose/gram ± SD for n = 4