EJNMMI Radiopharmacy and Chemistry

Table 2 Synthesis of 6-[¹⁸F]FDOPA starting from different precursors using different catalysts

From: Advances in the automated synthesis of 6-[¹⁸F]Fluoro-L-DOPA

Entry	Precursor	Catalyst	Time (min)	RCY (%)	A_m (GBq/μmol)	ee (%)	Ref.
1		21	110	10–15	74–185	95	(Guillouet et al., 2001)
2		21	80–85	7–15*	n.d.	90	(Zhang et al., 2002)
3		21	100	25–30*	n.d.	> 95	(Lemaire et al., 2004)
4		22 and (s)-NOBIN	110–120	16 ± 5	n.d.	96	(Krasikova et al., 2004)
5		21	120	20 ± 4	> 50	≥ 95	(Shen et al., 2009)
6		23/24	63	33–39^a	> 750	> 97	(Libert et al., 2013)

Unless otherwise stated, RCYs are given non-decay corrected (ndc). ^adecay corrected (dc); n.d.: not determined

Back to article page