Fig. 6

Maximum intensity projections (MIPs) of μSPECT/CT scans in LNCaP xenograft-bearing mice, acquired 24 h p.i. of (a) [¹⁷⁷Lu]Lu-3 (carbamate I) (3.2 MBq) (b) [¹⁷⁷Lu]Lu-6 (proinhibitor II) (5.3 MBq) (c) [¹⁷⁷Lu]Lu-7 (proinhibitor III) (4.5 MBq) (d) [¹⁷⁷Lu]Lu-10 (alkyne) (9.7 MBq) (e) [¹⁷⁷Lu]Lu-11 (tetrazole) (7.0 MBq) (f) [¹⁷⁷Lu]Lu-PSMA-10 (1) (2.8 MBq). For clear comparison, all images were scaled to the same maximum uptake value (2.5% ID/mL). Arrows indicate apparent tumor uptake in (a), (e) and (f). No μSPECT/CT image is displayed for [¹⁷⁷Lu]Lu-5 (proinhibitor I), as ingestion of radioactive animal feed led to putative high activities in stomach and intestine. Therefore, all values of this mouse (= mouse 3) from the respective biodistribution study and also its μSPECT/CT image were excluded. Static images were acquired post mortem (CO₂ asphyxiation and cervical dislocation) and after cardiac puncture with an acquisition time of 45 min. Further biodistribution studies were performed after the scan and included in the calculation of % ID/g values provided by Figs. 3 and 4 within this manuscript and Table 3 in the supporting information