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EJNMMI Radiopharmacy and Chemistry
Fig. 2 | EJNMMI Radiopharmacy and Chemistry

Fig. 2

From: Highlight selection of radiochemistry and radiopharmacy developments by editorial board (January–June 2020)

Fig. 2

TCO-functionalized nanostars passively accumulate at the tumor site. After several days, a radioligand is injected that will bind to the TCO-functionalized nanostars at the tumor site via the bioorthogonal IEDDA click reaction. Unreacted radioligands are cleared from the blood circulation rapidly (within hours), resulting in minimal radiation doses to off-target tissues. (Reprinted from Goos et al. (2020), with permission from Elsevier)

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