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Fig. 3 | EJNMMI Radiopharmacy and Chemistry

Fig. 3

From: Improved non-invasive positron emission tomographic imaging of chemotherapy-induced tumor cell death using Zirconium-89-labeled APOMAB®

Fig. 3

Effect of chemotherapy on tumor and normal tissue uptake of different radioconjugates of chDAB4. Representative whole-body PET images of a single mouse from each group during the course of the experiment are shown. Color scale indicates relative extent of tissue uptake of radioactivity. Asterisks in black at Day 5 time point indicate blood pool. Arrows in white at Day 8 time point indicate tumors in right flank of each mouse (n = 5) (a). Ex vivo biodistribution of the [89Zr]ZrIV- and [124I]I-labeled chDAB4 on Day 8 was measured using the HIDEX counter (b). Tumor uptake of [124I]I- and [89Zr]ZrIV-labeled chDAB4 during the course of the experiment was quantified and expressed as Percent Injected Dose per gram (%ID/g) using PMOD® software (c). All data points are means ± SD

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