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Table 1 Common steps for the automated radiosynthesis of [18F]LBT999 on TRACERlab FXFN and AIO modules

From: Fully automated radiosynthesis of [18F]LBT999 on TRACERlab FXFN and AllinOne modules, a PET radiopharmaceutical for imaging the dopamine transporter in human brain

1) Azeotropic drying and complex [18F]KF/K222 formation 1- [18F]Fluoride trapping on a QMA after production and transfer from the cyclotron
2- Elution of [18F]Fluoride in the reactor with a solution of K222/K2CO3
3- Azeotropic drying of [18F]Fluoride with successive addition of acetonitrile
2) [18F]radiofluorination of 4 1- Addition of the precursor 4
2- [18F]Radiofluorination
3) Purification of [18F]LBT999 1- Cooling and Dilution of the crude mixture with water or a solution of water in presence of Na-Asc (0.5%).
2- Pre-purification on C18 and washing with water or a solution of water in presence of Na-Asc (0.5%).
3- Elution of crude product and injection into the HPLC loop
4- HPLC Purification
5- Collection of the product
6- Trapping on C18 cartridge and washing
4) Formulation and dispensing of [18F]LBT999 1- Elution with 10% EtOH and saline (0.9%) or saline (0.9%) with Na-Asc (0.5%)
2- Transfer of formulated [18F]LBT999 and vial dispensing after sterile filtration