Skip to main content
EJNMMI Radiopharmacy and Chemistry

Table 2 Conversion of aliphatic and aromatic amines to their corresponding [carbonyl-11C] formamide derivatives

From: Rapid one-pot radiosynthesis of [carbonyl-11C]formamides from primary amines and [11C]CO2

  1. Reaction conditions for all entries: [11C]CO2 was bubbled at 0 °C for 2 min in a solution of amine (4.7 μmol, 1 equiv.) and BEMP (3.7 equiv.) in diglyme (75 μL). At end of delivery (EOD, 2 min) a solution of POCl3 (11.5 equiv.) in diglyme (75 μL) was added in the same vial, allowing the reaction for 2 min at 0 °C. A solution of NaBH4 (2.67 mg, 15 equiv.) in diglyme (50 μL) was then added. The reduction occurred at 0 °C for 10 min. n = 3. RCY (non-isolated) is the percentage of product radioactivity divided by total radioactivity observed in an analytical HPLC chromatogram.
  2. an = 1
Back to article page