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EJNMMI Radiopharmacy and Chemistry

Table 2 Comparison of [68Ga]Ga-FAPI-04 and [68Ga]Ga-DOTA.SA.FAPi: SUVmean values of μPET measurements at 60 min p.i. with the corresponding tumor models. The values of the FAPI-04 component are obtained from the reference literatures (Lindner et al. 2018; Watabe et al. 2020)

From: Targeting fibroblast activation protein (FAP): next generation PET radiotracers using squaramide coupled bifunctional DOTA and DATA5m chelators

Compound

[68Ga]Ga-FAPI-04

[68Ga]Ga-DOTA.SA.FAPi

Tumormodel

HT-1080 FAP

PANC-1 / MIA-PaCa-2

HT-29

Organ

SUVmean(60 min p.i.)

Heart

0.16

0.17

0.15

Muscle

0.06

0.03

0.18

Kidney

0.33

0.36

0.27

Liver

0.11

0.67

0.22

Tumor

0.45

0.14 / 0.11

0.75

  1. The values from references were read from the graphs and therefore do not indicate precise values
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