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EJNMMI Radiopharmacy and Chemistry

Table 1 Comparison of the three types of cassettes

From: Automated [18F]PSMA-1007 production by a single use cassette-type synthesizer for clinical examination

Cassette material

Fluoro- elastomer

(n = 3)

PharMed® BPT

(n = 3)

Silicone

(n = 3)

Silicone

(n = 7)

Precursor form

TFA salt

TFA salt

TFA salt

ACE salt

Activity yields (MBq)

5437 ± 504 *

5353 ± 273 *

5507 ± 115 *

7906 ± 1216 *

Radiochemical yield (%)

43 ± 7

41 ± 1 *

41 ± 1 *

56 ± 4 *

Radiochemical purity (%)

95 ± 1 *

95 ± 0 *

95 ± 0 *

97 ± 0 *

PSMA-1007 (μg/mL)

8.5 ± 3.1 *

0.3 ± 0.0

0.3 ± 0.0 *

0.4 ± 0.0 *

Molar activity (GBq/μmol)

46 ± 19 *

1184 ± 161

1411 ± 169

1463 ± 189 *

Highest single chemical impurity (μg/mL)

1.5 ± 0.2

1.0 ± 0.0

1.4 ± 0.2

1.2 ± 0.3

Total chemical impurities (μg/mL)

4.1 ± 0.4

3.0 ± 0.6

4.2 ± 0.3

4.1 ± 0.7

  1. *P < 0.05 vs Silicone, ACE salt
  2. Activity yields, radiochemical yield, radiochemical purity, PSMA-1007, molar activity, highest single chemical impurity, and total chemical impurities were compared among the three types of cassettes using precursor trifluoroacetic acid (TFA) salt and silicone cassette using acetic acid (ACE) salt precursor (p < 0.05 by unpaired t-test compared to silicone, precursor of ACE salt)
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