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Table 1 Comparison of the three types of cassettes

From: Automated [18F]PSMA-1007 production by a single use cassette-type synthesizer for clinical examination

Cassette material Fluoro- elastomer
(n = 3)
PharMed® BPT
(n = 3)
Silicone
(n = 3)
Silicone
(n = 7)
Precursor form TFA salt TFA salt TFA salt ACE salt
Activity yields (MBq) 5437 ± 504 * 5353 ± 273 * 5507 ± 115 * 7906 ± 1216 *
Radiochemical yield (%) 43 ± 7 41 ± 1 * 41 ± 1 * 56 ± 4 *
Radiochemical purity (%) 95 ± 1 * 95 ± 0 * 95 ± 0 * 97 ± 0 *
PSMA-1007 (μg/mL) 8.5 ± 3.1 * 0.3 ± 0.0 0.3 ± 0.0 * 0.4 ± 0.0 *
Molar activity (GBq/μmol) 46 ± 19 * 1184 ± 161 1411 ± 169 1463 ± 189 *
Highest single chemical impurity (μg/mL) 1.5 ± 0.2 1.0 ± 0.0 1.4 ± 0.2 1.2 ± 0.3
Total chemical impurities (μg/mL) 4.1 ± 0.4 3.0 ± 0.6 4.2 ± 0.3 4.1 ± 0.7
  1. *P < 0.05 vs Silicone, ACE salt
  2. Activity yields, radiochemical yield, radiochemical purity, PSMA-1007, molar activity, highest single chemical impurity, and total chemical impurities were compared among the three types of cassettes using precursor trifluoroacetic acid (TFA) salt and silicone cassette using acetic acid (ACE) salt precursor (p < 0.05 by unpaired t-test compared to silicone, precursor of ACE salt)